|
Symbol Name ID |
Pak3
p21 (RAC1) activated kinase 3 MGI:1339656 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Microcephaly |
Drooling |
Hydrocephalus |
Clumsiness |
Delayed speech and language development |
Poor speech |
Anxiety |
Psychosis |
Aggressive behavior |
Hyperactivity |
Restlessness |
Agitation |
Short attention span |
Intellectual disability |
Intellectual disability, severe |
Brisk reflexes |
Global developmental delay |
Delayed gross motor development |
Delayed ability to walk |
Seizure |
Bilateral tonic-clonic seizure |
Generalized non-motor (absence) seizure |
| Disease(s) Associated with PAK3 | ||||||||||||||||||||||
| non-syndromic X-linked intellectual disability 30 |
| Mouse Phenotypes | nervous system phenotype |
abnormal neuron differentiation |
abnormal dendritic spine morphology |
abnormal dentate gyrus neuron dendrite morphology |
abnormal synapse morphology |
abnormal synaptic vesicle number |
abnormal neuron physiology |
enhanced long-term potentiation |
reduced long-term potentiation |
abnormal miniature excitatory postsynaptic currents |
reduced long-term depression |
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| Availability | Mouse Genotype | |||||||||||
| Pak3tm1Zpj/Pak3tm1Zpj | ||||||||||||
| Pak3tm1.1Rpo/Y | ||||||||||||
| Tg(Camk2a-AIDPak)21Stl/0 | * | |||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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